Objective To investigate useful predictive factors relating with the prognosis of Wilson disease (WD).Methods Clinical and laboratory data were collected from 75 consecutive paediatric WD pa-tients with liver type.They were divided respectively into two groups: group A ( relieved after treatment ) and group B ( progressive or death after treatment ) according to their effect with therapy.The clinical and laboratory indicators between the two groups were compared , and multivariate logistic regression analysis was used to ex-plore the relationship between relevant indicators and prognosis.Results The levels of prothrombin time , ser-um total bilirubin, transaminase, uric acid, albumin and Apolipoprotein A1 (ApoA1) had significant differ-ences between two groups ( P<0.05 ).The level of prothrombin time , serum total bilirubin , Albumin and ApoA1 were independent factors to prognosis by Logistic regression analysis (P<0.05).Conclusions Inde-pendent indicators of poor prognosis in patients with liver hepatic degeneration included albumin , ApoA1, pro-thrombin time and serum total bilirubin.%目的：探讨可预测肝型肝豆状核变性（ WD ）患者预后的相关因素。方法收集了75例肝型WD患者的临床和实验室资料，根据他们的预后分为肝A组50例（治疗后好转）和肝B组25例（治疗后恶化放弃治疗或死亡）。比较两组临床及实验室指标的差异，采用多因素Logistic回归分析探讨相关指标与患者预后的关系。结果肝A组和肝B组之间凝血酶原时间、血清总胆红素、AST、尿酸、血清白蛋白、载脂蛋白A1（ApoA1）比较差异具有统计学意义（P均＜0.05）；多因素Logistic回归分析结果显示凝血酶原时间、血清总胆红素、白蛋白、 ApoA1是与肝型WD患者预后相关的独立因素（ P均＜0.05）。结论凝血酶原时间、血清总胆红素、白蛋白、 ApoA1可作为评价WD患者预后的指标。
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