血清总胆汁酸在肝脏疾病诊断中的应用

摘要

目的：探讨常见肝病中血清总胆汁酸（TBA）及4种肝酶的差异。方法152例肝病患者为肝病组，128名健康志愿者为对照组。比较2组患者血清 TBA、AST、ALT、γ-谷氨酰转移酶（GGT）、碱性磷酸酶（ALP）水平及其异常率。比较肝病组血清 TBA 与 AST、ALT、GGT、ALP 异常率。结果肝病组患者血清 TBA、AST、ALT、GGT、ALP 水平、异常率均明显高于对照组（P ＜0.01）。肝病组患者血清 TBA 异常率明显高于4种肝酶异常率（P ＜0.05）。结论在急慢性肝炎、肝硬化、肝癌疾病中，TBA 异常率高于4种肝酶指标，且对潜在性肝细胞损害有早期诊断价值。%Objective To investigate the difference between serum total bile acid and four types of liver enzymes in diagnosis of common liver diseases.Methods 1 52 patients with liver diseases were assigned into the liver disease group and 1 28 healthy volunteers into the control group.Serum TBA,AST,ALT,GGT, ALP levels and abnormal rates were statistically compared between two groups.Furthermore,differences of ab-normal rates between serum TBA and AST,ALT,GGT,ALP in liver disease group were compared.Results In the liver disease group,serum levels and abnormal rates of TBA,AST,ALT,GGT and ALP were signifi-cantly higher compared with those in the control group (P <0.01 ).In addition,the abnormal rate of serum TBA was significantly higher than those of four types of liver enzymes (P <0.05)in liver disease group.Con-clusion In acute and chronic hepatitis,liver cirrhosis and liver cancer,the abnormal rate of total bile acid was higher than those of four types of liver enzymes and it had early diagnostic value for potential liver cell dam-ages.