5-羟色胺转运体基因多态性对儿童期虐待与青少年攻击行为的调节作用

摘要

Objective To explore 5 —HTTLPR and child abuse predict aggressive behavior among Chinese adolescents. Methods We examined the effects of child maltreatment (measured using the child trauma questionnaire [CTQ]), polymorphisms in 5— HTTLPR and their interactions with regard to aggressive behavior (assessed by the Child Behavior Checklist for Youth Self—Report [YSR]) for a group of 600 Chinese adolescents using a linear regression analysis. Results Physical abuse, sexual abuse and emotional abuse had main effect irrespectively (P < 0. 01). 5- HTTLPR had no effect (P > 0. 05). A significant interaction between the 5— HTTLPR and sexual abuse on aggressive behavior for male adolescents (P < 0. 05) was identifies. Adolescents with "SS" genotype of 5— HTTLPR were more prone to commit aggressive behavior than "SL" and "LL"genotypes when suffered sexual abuse. There was no any such correlation found in females. Conclusions Aggressive behaviors in adolescents are modulated by a G —E interaction involving 5—HTTLPR polymorphisms and childhood abuse experience may result in differential propensity to aggressive behaviors among the subtypes of childhood maltreatment and between the two genders.%目的 探讨5-羟色胺转运体(5-hydroxy tryptamine transporter,5-HTT)基因多态性与儿童期虐待对青少年攻击行为的调节作用.方法 使用CTQ(儿童创伤经历问卷)评定儿童期虐待,用YSR(儿童行为量表CBCL自我报告版)评定攻击行为,运用线性回归模型对600名中国青少年检验其儿童期虐待、5-HTTLPR基因多态性对攻击行为的主效应及两者间的基因-环境交互作用.结果 儿童期躯体虐待,性虐待,情感虐待对攻击行为始终有预测效应(P＜0.01),5-HTTLPR基因型无主效应(P＞0.05)；此外,男性青少年5-HTTLPR与性虐待对攻击行为有交互作用(P＜0.05),SS基因型个体在受到性虐待后较SL、LL基因型个体更易出现攻击行为；女性则无任何交互作用.结论 儿童期虐待经历与青少年攻击行为受到5-HTTLPR的调节,不同性别青少年对不同虐待类型存在敏感性差异.