奥美沙坦酯对原发性高血压患者血压和心率变异性的影响

摘要

Objective To investigate the effect of olmesartan on blood pressure and heart rate variability in patients with pri -mary hypertension .Methods Forty-six patients with primary hypertension were selected as the treatment group , which was given olme-sartan.Another 40 health examinees at the same period were chosen as the control group .The effect of olmesartan on heart rate variabil-ity(SDNN, SDANN, RMSSD, PNN50)and effect on the reduction of blood pressure were compared both before and after treatment , and comparisons were made with those of the control group .Results Before medication , the indicators of SDNN , SDANN, RMSSD and PNN50 for the treatment group were all lower than those of the control group .However, after medication, those indicators were elevated than those before medication, but was still lower than those of the control group , with statistical significance (P<0.05).After treat-ment , systolic blood pressure , diastolic blood pressure and heart rate were all lower than those before treatment , also with statistical sig-nificance (P<0.05).No statistical significance could be seen, when comparisons were made with those of the control group (P>0.05).Conclusion The application of olmesartan in patients with primary hypertension could not only significantly decrease blood pressure, but improve patient heart rate variability .%目的：探讨奥美沙坦酯对原发性高血压患者血压和心率变异性的影响。方法选择原发性高血压患者46例作为治疗组，给予奥美沙坦酯治疗，另选同期健康体检者40例作为对照组，比较治疗组治疗前后心率变异性指标（ SDNN、SDANN、RMSSD、PNN50、LF、HF、LF/HF）的变化及降压效果，并与对照组比较。结果治疗组治疗前SDNN、SDANN、RMSSD、PNN50均低于对照组，治疗后各项指标均较治疗前升高（P＜0．01），但仍低于对照组（P＜0．05）。治疗组治疗后收缩压、舒张压、心率均低于治疗前，差异有统计学意义（ P＜0．05）；与对照组比较差异无统计学意义（ P＞0．05）。结论原发性高血压患者应用奥美沙坦酯可显著降低血压，并能够显著改善患者心率变异性。