阻塞性睡眠呼吸暂停综合征40例发病特点分析

摘要

Objective To study clinical features of obstructive sleep apnea syndrome (OSAS) in senile patients.Methods Forty cases of OSAS that were diagnosed and treated in the pulmonary department of our hospital from Mar.2012 to Aug.2013 were chosen as the observation group, and another 40 healthy adults were assigned as the control group.The levels of leptin, C reactive pro-tein ( CRP) and basic diseases in the 80 study subjects were closely observed, and then, clinical features of the patients with OSAS were analyzed.Results Compared with the control group, the patients in the observation group mostly had such primary diseases as o-besity, cardiovascular and cerebrovascular diseases, and the levels of leptin and CRP were significantly higher than those of the control group, with statistical significance (P<0.05 or <0.01).Conclusion Serum leptin and CRP levels in the OSAS patients could rea-sonably represent the seriousness of the disease, and they might have synergistic effects in the development of OSAS.%目的：探讨阻塞性睡眠呼吸暂停综合征（ OSAS）患者的临床发病特点。方法选取2012年5月至2013年8月在我院呼吸科诊断治疗的40例OSAS患者作为观察组，另外选取40例健康成年人作为对照组，观察纳入的80例患者血清中瘦素（ leptin）、C反应蛋白水平（ CRP）及基础病种，分析OSAS患者的临床发病特点。结果与对照组比较，观察组患者多有肥胖、心脑血管疾病等原发性疾病，观察组患者血清中瘦素及C反应蛋白水平[（170．16±19．77）ng／L，（20．78±4．39）μg／L]明显高于对照组组[（51．97±8．68）ng／L，（4．35±0．92）μg／L]，差异均有统计学意义（P＜0．05或＜0．01）。结论 Leptin及CRP水平可以较好的反映OSAS患者的严重程度相关，两者可能在OSAS的发展过程中有协同作用。