加味青蒿鳖甲汤治疗晚期肺癌癌性发热32例

摘要

目的 探讨加味青蒿鳖甲汤在治疗晚期肺癌癌性发热和改善患者生存质量方面的作用.方法 将符合研究标准64名患者随机分为治疗组32例和对照组32例,治疗组加味青蒿鳖甲汤,水煎,每日1剂,分2次口服,7d1个疗程.对照组塞来昔布胶囊,0.2g,每日2次,7d1个疗程.观察治疗前后2组患者的体温及生活质量评分.结果 治疗组有效率65.7％,高于对照组(59.4％),P＜0.05；治疗组KPS增加值≥10分者占46.9％,高于对照组(9.4％),P＜0.05；治疗组无毒副反应出现.结论 治疗晚期肺癌癌性发热,加味青蒿鳖甲汤治疗组与塞来昔布胶囊对照组相比,有效率明显提高,在改善患者生存质量方面的作用显著,副作用少.%OBJECTIVE To investigate the therapeutic effects of Modified Qinghao Biejia Decoction for fever of advanced lung cancer and its assistance to improve patients' quality of life. METHODS 64 cases conforming to the experimental standard were equally randomized into treatment group given 1 bag of Modified Qinghao Biejia Decoction a day, bid for 7 days as a course; and control group taking Celecoxib capsules 0.2 g, bid in the same period to observe patients' temperature and their KPS. RESULTS The effective rate and the percentage of patients with KPS≥10 in treatment was 65.7% and 46.9%, higher than 59.4%(P<0.05) and 9.4%(P<0.05) of control group. Treatment group did not show any toxic side effects, either. CONCLUSION The effective rate of treatment group using Modified Qinghao Biejia Decoction is conspicuous higher than that of Celecoxib group. It also plays a significant role in improving patients' quality of life without side effects.