目的 通过对复发性外阴阴道假丝酵母菌病(RVVC)患者同时进行支原体检测与相应治疗,探讨支原体感染对诱发RVVC中的作用.方法 回顾性分析过去3年收治的250例诊断为RVVC患者,按随机数字表法分为实验组(100例)与对照组(150例),实验组入组同时行支原体检测及药敏试验,实验组RVVC合并支原体阳性者(实验1组)同时予常规抗真菌及抗支原体治疗,实验组RVVC合并支原体阴性者(实验2组)仅给予抗真菌治疗;对照组不检测支原体,治疗仅给予常规抗真菌治疗.结果 实验组中,69%患者(69例)同时合并支原体感染,2者同时治疗后治愈率为92.75%(64例);实验组中支原体阴性者,治愈率为90.32%(28例);对照组治愈率为40.67%(61例).实验1、2组与对照组治愈率比较差异有统计学意义(P＜0.01).结论 支原体感染对诱发女性生殖道RVVC有一定作用,给予同时治疗可以降低RVVC复发率.%Objective To investigate the role of mycoplasma infection in recurrent vulvovaginal candidiasis (RVVC) through the detection and treatment of mycoplasma. Methods Data of 250 patients diagnosed with RVVC in past 3 years were retrospectively analyzed. Theses patients were randomly divided into two groups. Patients in experimental group (n=100) underwent mycoplas-ma detection and drug susceptibility testing, and then mycoplasma positive RVVC patients were given conventional anti-fungal and anti-mycoplasma treatment and mycoplasma negative RVVC patients were only given anti-fungal treatment. The control group (n=150) only received conven-tional anti-fungal therapy. Results Among the 100 patients in experimental group, RVVC was complicated by mycoplasma infection in 69 (69%), and clinical cure was achieved in 64 (92.75%). Among mycoplasma negative RVVC patients, clinical cure was achieved in 28 (90. 32%). Among the 150 patients in control group, clinical cure was achieved in 61 (40. 67%). Experiment 1 and 2 compared with the control group the cure rate difference was statistically si-gaificant(P<0. 01). Conclusion Mycoplasma infection can induce RVVC. Simultaneous treat-ment of mycoplasma infection and RVVC can reduce recurrence of RVVC.
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