雌激素受体α基因XbaⅠ、PvuⅡ位点基因多态性与南昌地区绝经后妇女骨密度的关系

摘要

目的 探讨雌激素受体α(ERα)基因XbaⅠ、PvuⅡ位点基因多态性与南昌地区绝经后妇女骨密度(BMD)的关系.方法 选取符合调查要求的160名绝经后妇女,通过双能X线吸收法测量BMD,PCR-RFLP技术检测ERα基因PvuⅡ和XbaⅠ限制性酶切位点基因多态性.结果 XbaⅠ位点XX、Xx、xx 3个基因组的腰椎L1-L4、股骨颈、大转子、Wards三角的BMD差异无统计学意义(P>0.05);PvuⅡ位点PP、Pp、pp 3个基因组的腰椎L1-L4、股骨颈、大转子、Wards三角的BMD差异无统计学意义(P>0.05).结论 ERα基因XbaⅠ、PvuⅡ位点基因多态性与南昌地区绝经后妇女BMD无关.%Objective To study the relationship between Xba Ⅰ and Pvu Ⅱ polymorphisms of es-trogen receptor a (ERa) gene and bone mineral density(BMD) in postmenopausal women in Nan-chang. Methods The BMD was measured by dual energy X-ray absorptiometry and Pvu II and Xba I polymorphisms were detected by PCR-RFLP in 160 postmenopausal women. Results There were no relationship between XX, Xx and xx genotypes of Xba I polymorphism or PP,Pp and pp genotypes of Pvu TJ polymorphism and BMD of lumbar spine (L1- L4), femoral neck, greater trochanter and Ward's triangle(P>0. 05). Conclusion There were no relationship be-tween polymorhisms of Xba I and Pvu TJ genotypes and BMD in postmenopausal women in Nan-chang.