高血压患者血清胆红素与脉搏波速度相关性研究

摘要

目的 探讨高血压患者血清胆红素与脉搏波速度的关系.方法 应用康普乐全自动动脉硬化检测系统检测508例确诊为原发性高血压患者的颈-股动脉脉搏波速度(CF-PWV),并检测空腹血清总胆红素.将总胆红素＞11 μmol·L-1者作为高胆红素组(n＝ 221),总胆红素≤11μmol·L-1者作为低胆红素组(n＝287),对血清总胆红素与CF-PWV值进行相关性分析.结果 高胆红素组CF-PWV值为(9.04士1.20)m·s-1低于低胆红素组的(10.89±2.18)m·s-1,2组比较差异有统计学意义(P＜0.01)；血清总胆红素与CF-PWV值呈负相关(r＝-0.636,P＜0.01).结论 高血压患者血清总胆红素与脉搏波速度呈负相关.%Objective To study the relationship between serum bilirubin and pulse wave velocity (PWV) in hypertensive patients.Methods Carotid-femoral PWV(CF-PWV) was determined by using Complior SP automatic arteriosclerosis measurement system in 508 patients with essential hypertension.According to the fasting serum total bilirubin levels,patients were divided into high bilirubin group (＞11 μmol · L-1,n＝221) and low bilirubin group (≤11 μmol · L-1,n＝287).The correlation between serum total bilirubin and CF-PWV was analyzed.Results Compared with low bilirubin group,CF-PWV significantly decreased in high bilirubin group [(9.04±1.20)m · s-1 vs (10.89±2.18)m · s-1,P＜0.01].There was a negative correlation between serum total bilirubin levels and CF-PWV (r＝-0.636,P＜0.01).Conclusion Serum total bilirubin levels are negatively correlated with PWV in hypertensive patients.