环境胁迫下细菌非编码小RNA对基因表达的调控

摘要

Bacterial small non-coding RNA(sRNA)is a type of RNA molecule withlength ranging from 50 to 500 nucleotides and located in the intergenic regions. In the bacterial genome, sRNA can be tran-scribed but cannot be translated into protein.With the development of bioinformatics and RNA sequencing tech-nology,more and more attention have been paid to sRNA's function.In the changing environment,bacteria will encounter different types of survival pressure.sRNA plays an important role in the adaptation to different bio-logical and environmental pressures. In this paper, the regulation of bacterial small non-coding RNA on gene expression under environmental stress will be reviewed, which is of great importance to reveal the bacterial gene post-transcriptional regulation and biological adaptive evolution.%细菌非编码小RNA(sRNA)是长度约为50~500个核苷酸的RNA分子,其编码基因位于基因间区域,在细菌基因组中可被转录但不被翻译为蛋白质.随着生物信息学和RNA测序技术的发展,sRNA功能受到广泛关注.在不断变化的环境中,细菌遇到各种各样的生存压力,sRNA通过感应环境变化调节相应基因的表达,在细菌适应环境的过程中发挥了重要作用.本文对环境胁迫下细菌sRNA的表达变化和其对基因的表达调控进行综述,揭示sRNA对细菌基因转录后调控、生物适应性进化等生命过程的重要意义.