Objective To evaluate the bactericidal effect of 17% EDTA combined with 1% NaOCl in ultrasonic irrigation of root canal.Methods Totally 100 single-rooted teeth in 100 patients with chronic periapical periodontitis were divided into five groups randomly of 20 teeth each. All root canals were instrumented by hand with stainless steel endodontic instruments and irrigated by ultrasound with 2.5% NaOCl (group A）,1% NaOCl (group B）, 17% EDTA+1% NaOCl （group C）, 17% EDTA （group D）, and saline（group E）. Totally 30 μl of liquid sample was obtained from each root canal and examined for anaerobic bacteria colony counting before and after root canal instrumentation.Results After root canal instrumentation, the number of anaerobic bacteria colony was significantly reduced in all 5 groups (P＜0.01) . The colony number in group C was less than that in group B (P＜0.05), and than that in group D and E (P＜0.01), there was no difference between group A and group C (P＞0.05).Conclusion Ultrasonic combined with 17% EDTA+1% NaOCl irrigation has better bactericidal effects of root canal irrigation.%目的 研究17%EDTA+1%NaOCl与超声波联合应用杀灭感染根管内厌氧菌的效果.方法 将100例慢性根尖周炎患者共100颗患牙随机分为A组(2.5%NaOCl)、B组(1%NaOCl)、C组(17%EDTA+1%NaOCl)、D组(17%EDTA)、E组(生理盐水)5组,每组各20颗患牙,采用手持器械预备根管后,分别采用2.5%NaOCl、1%NaOCl、17%EDTA+1%NaOCl、17%EDTA、生理盐水超声法冲洗根管,根管预备前后分别取样进行厌氧培养.结果 根管预备前后,五组根管内厌氧菌减少程度之间有显著性差异(P＜0.01),其中C组(17%EDTA+1%NaOCl组)厌氧菌的减少程度明显大于B组(1%NaOCl组)(P＜0.05),显著大于D组(17%EDTA组)和E组(生理盐水组)(P＜0.01),与A组(2.5%NaOCl组)之间无显著性差异(P＞0.05).结论 17%EDTA+1%NaOCl与超声波联合应用可有效杀灭根管内的厌氧菌,其抗菌效果优于单独使用的1%NaOCl,与单独使用的2.5%NaOCl效果相近,是一种有效的根管冲洗液组合.
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