循环肿瘤DNA在复发转移性乳腺癌中的研究进展

摘要

随着医疗技术的发展,精准医疗概念的提出,循环肿瘤DNA(circulating tumor DNA,ctDNA)检测在肿瘤治疗过程中受到极大的关注.ctDNA携带肿瘤相同遗传信息,反应肿瘤负荷,用于肿瘤早期筛查,耐药性研究,复发转移监测,预后评估.本文深入探讨循环肿瘤DNA在复发移性乳腺癌中的作用,使其成为乳腺癌患者监测转移和预后的常规的检测指标,并有助于明确耐药性产生的机制,发现乳腺癌转移治疗的新靶点.%With the development of the medical technology,concept of precision medical treatment proposed,consid-erable attention has been paid to the utility of circulating tumor DNA (ctDNA)detection in cancer.ctDNA carries the same genetic information of the tumor and reacts with the tumor load.It is used for early cancer screening,drug resist-ance,recurrence and metastasis,and prognosis evaluation.In this paper,we will further explore the role of circulating tumor DNA in recurrent and metastatic breast cancer,making it a routine detection index for monitoring metastasis and prognosis in breast cancer patients,and help to clarify drug resistance,and find a new target for breast cancer metasta-sis therapy.