晚期卵巢癌术后早期顺铂腹腔热灌注化疗临床研究

摘要

Objective :To evaluate effects of early postoperative intraperitoneal chemotherapy( IPC ) on advanced ovarian carcainoma. Methods: From 2002 to 2005,40 patients with advanced ovarian carcainoma were treated with IPC after radical operation in our hospital, results were compared with 40 cases treated with intravenous chemotherapy ( IVC ). Results: All patients in IPC group and IVC group received all the 6 phases of chemotherapy. Compared with IVC, IPC treatment had advantages of lower relapse rate, 3 - year survival rate ( 70％ ) ,5 - year survival rate ( 55％ ) in IPC group were higher than those in IVC group ( 42.5％ and 32.5％ ,respectively,P ＜0.05 ). Conclusion: For patients with advanced ovarian carcainoma, treatment with IPC at the early postoperation period after radical operation has less side effect,higher survival rate and better life quality.%目的:评价卵巢癌术后早期腹腔热灌注化疗疗效.方法:将2002年1月-2005年12月我科收治晚期上皮性卵巢癌减瘤术后患者80例,随机单盲分成实验组40例(紫三醇联合卡铂方案静脉全身化疗联合腹腔热灌注顺铂化疗组)与对照组40例(紫三醇联合卡铂方案静脉全身化疗组).分析两组生存率、复发情况及不良反应.结果:80例病人均完成全部6周期静脉全身化疗,实验组静脉全身化疗期间同期完成腹腔热灌注化疗6次.实验组患者术后3年生存率,5年生存率70%,55%,高于静脉全身化疗组42.5%,32.5%,不良反应可耐受.结论:术后早期腹腔热灌注化疗是晚期卵巢癌减瘤术后的有效辅助化疗,不良反应可耐受,可提高晚期卵巢癌病人的生存率和生活质量.