Vasculogenic mimicry(VM) is a brand - new tumor blood essels mode which is independent of angiogen-esis. More and more research found that the formation of VM have a close relation with the plasticity of tumor cells themselves and tumor stem cells. In addition,the tumor microenvironment such as the extracellular matrix remodeling and hypoxia also play an important role in the forming process of vasculogenic mimicry. In recent years,the related research about mechanism to tumor vasculogenic mimicry has made a lot of progress. This provides new ideas and direction for seeking the key role of VM inhibition targets, screening effective drug. This article gave an outline of VM and summarize the formation mechanism of vasculogenic mimicry and the research status about the oncotherapy.%血管生成拟态是独立于血管生成的一种全新肿瘤血管模式.越来越多的研究发现血管生成拟态的形成机制和肿瘤细胞自身的可塑性及肿瘤干细胞关系密切,另外,肿瘤微环境如细胞外基质重塑、缺氧等在血管生成拟态形成过程中也有很重要的作用.近年来,血管生成拟态形成机制的相关研究已经取得了很大进展,为寻找抑制VM的关键作用靶点、筛选有效的治疗药物提供了新的思路和方向.本文就血管拟态的发现、形成机制及其在肿瘤治疗中的研究现状等方面做一综述.
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