新疆地区不同民族胃癌患者HER2蛋白表达与临床病理学特征的关系

摘要

目的：利用新疆地区有利条件探究胃癌患者HER2eu表达与民族及临床病理特征的关系。方法：随机选取2010年-2012年新疆维吾尔自治区人民医院收治的120例原发胃癌患者（胃食管交界处肿瘤33例，胃体部肿瘤35例，胃窦部肿瘤52例），应用免疫组织化学（ immunohistochemistry，IHC）法检测胃癌患者的HER2eu表达情况，应用新版《胃癌HER2检测指南》评分标准进行评分。数据分析采用SPSS 17.0统计软件。结果：120例胃癌组织中20例（16.7％）HER2eu（﹢﹢﹢），胃食管交界处肿瘤阳性率明显高于胃体/胃窦肿瘤（33.3％ vs 10.3％，P＝0.005）。肠型胃癌阳性率显著高于弥漫性/混合型胃癌（26.7％ vs 6.7％，P＝0.001）。汉族与少数民族（维族、哈族）之间HER2eu蛋白阳性率（15.7％ vs 17.4％，P＝0.407）无明显差异。结论：肠型胃癌与胃食管交界处肿瘤是曲妥珠单抗联合化疗的主要适宜人群。%Objective:To study the relationship of HER2 expression and clinicopathological feature of gastiric cancer in Xinjiang. Methods:The HER2 status was evaluated using immunhistochemisty( IHC ). The new version of 〞HER2 Testing Guide of Gastric Cancer〞scoring criterion was used to assess HER2 protein expression. The data were analyzed using the statistical software SPSS 17. 0. Results:The positive rates in gastroesophageal junction tumors and intestinal type GC were higher than those in other location tumor and diffuse/mixed type GC(33. 3% vs 10. 3%, P=0. 005;26. 7% vs 6. 7%,P=0. 001),but were not correlated with different ethnic groups,gender and age. Con-clusion:Patients with intestinal type GC and gastroesophageal junction tumors may be the potential responders to tras-tuzumab combined with chemotherapy.