局部晚期胃癌FDP方案新辅助化疗的疗效观察

摘要

Objective:To explore the efficacy of neoajuvant chemotherapy interms of resectablity for the patients with advanced gastric cancer. Methods:All 44 patients with advanced gastric cancer were randomly divided into rou-tine surgical operation group and neoajuvant chemotherapy+surgical operation group. The patients were examined by CT before surgery. The patients in neoajuvant chemotherapy+surgical operation group received two cycles of neoaju-vant chemotherapy,and then were evaluated by CT. Results:In routine surgical operation group,the overall resect-ability rate was 81. 8%(18/22),and the curative resection rate was 45. 5%(10/22),18. 2%(4/22)was laparotomy rate. In neoauvant chemotherapy+surgical operation group,the overall respectability rate was 90. 9%(20/22),and the curative resection rate was 72. 7%(16/22),only 9. 1%(2/22)was laparotomy rate. No mortality was observed. There were no significant difference between two groups of toxicities. Conclusion:The overall resectability rate and the curative resection rate are increased in patients with advanced gastric cancer after neoajuvant chemotherapy.%目的：评估进展期胃癌患者新辅助化疗后再手术的临床疗效。方法：选择局部晚期胃癌患者44例分为两组：常规手术组和新辅助化疗+手术组，各22例，入院后行CT检查，新辅助化疗+手术组患者进行2个周期的新辅助化疗，再行CT复查，对比后进行手术治疗。结果：常规手术组肿瘤切除率为81.8%（18/22），获得根治性切除率为45.5%（10/22），剖腹探查率为18.2%（4/22）；新辅助化疗+手术组肿瘤切除率为90.9%（20/22），获得根治性切除率为72.7%（16/22），剖腹探查率为9.1%（2/22）。两组均无手术死亡病例，并发症发生率差异无显著性。结论：进展期胃癌患者在新辅助化疗后，再进行手术治疗，可以提高手术根治率和切除率。