扶正减毒颗粒防治急性放射性食管炎的临床观察

摘要

Objective:To study the effect of Fuzheng attenuated Particles for esoPhageal cancer Patients with acute radiation esoPhagitis. Methods:All 60 esoPhageal cancer Patients were randomly divided into treatment grouP(30 ca-ses)and control grouP(30 cases),treatment grouP were treated with radiotheraPy and Fuzheng attenuated Particles, control grouP were treated with radiotheraPy only. Results:Between treatment grouP and control grouP at all levels of acute radiation esoPhagitis incidence were different,the difference was statistically significant(P<0. 05). At the 6 week comPared with 4 week in treatment grouP acute radiation esoPhagitis ratio decreased(from 80% to 63. 3%),moderately and severe radioactive esoPhagitis(class Ⅱ and above)obviously decreased(33. 3% to 10%),KPS in-creasing rate was 43. 3%,decreasing rate was 6. 7%,in two grouPs difference was statistically significant. Conclu-sion:Fuzheng attenuated Particles can effectively reduce the incidence of acute radiation esoPhagitis,effectively im-Prove the functional status of Patients with radiotheraPy.%目的：使用扶正减毒颗粒干预食管癌患者放疗全程，观察急性放射性食管炎防治的临床效果。方法：60例食管癌患者随机分为治疗组和对照组（各30例），治疗组在放疗同时每日服用扶正减毒颗粒，对照组放疗期间未服用药物。分时段评价患者急性放射性食管炎分级以及KPS评分变化情况。结果：治疗组和对照组之间各级急性放射性食管炎发生率不同，差异有统计学意义（ P＜0.05）。第6周与第4周比较治疗组发生急性放射性食管炎的比例有所下降（从80%下降至63.3%），发生中重度放射性食管炎（Ⅱ级及以上）的比例明显下降（由33.3%下降至10%），KPS评分上升率为43.3%，下降率为6.7%，两组比较差异有统计学意义。结论：扶正减毒颗粒可以有效降低各级急性放射性食管炎发生率，有效提升放疗患者机体功能。