凋亡相关蛋白3（APR3）在宫颈鳞癌组织中的表达及临床意义

摘要

Objective:To explore the expression of APR3 in cervical squamous cell carcinoma(CSCC),cervical intraepithelial neoplasia(CIN),and normal cervical epithelium tissue,as well as to discuss the relationship between the expression and clinical pathology of cervical carcinomas.Methods:The 80 cases of cervical squamous cell carci-noma tissue paraffins were selected from the Affiliated Hospital of North Sichuan Medical College.All were pathologi-cally validated:90 cases of CIN and 30 cases of normal cervical epithelium tissue paraffin sections.We detected the expression of APR3 in cervical carcinomas,CIN,and normal cervical epithelium tissue by immunohistochemical SP method.Results:The positive expression of APR3 in CSCC was 81.25%,significantly higher than those in the control and CIN cases (P <0.01).The expression of APR3 in the post -therapy cervix (51.25%)was lower than the pre-therapy cervix (81.25%)(P <0.01).With the clinical stage increasing and pathological grade decreasing,the posi-tive expression rates of APR3 were significantly higher in cervical carcinomas.The positive expression rates of APR3 in human cervical carcinomas without lymph node metastasis was lower than those with lymph node metastasis (P<0.05).Conclusion:The expression of APR3 has a correlation with the development of cervical neoplasms.APR3 can promote the development of cervical lesions and bring negative effects to the prognosis.Chemoradiotherapy can in-fluence the expression level of APR3 in cervical carcinoma.%目的：探讨 APR3在不同宫颈组织的表达情况和临床病理意义。方法：免疫组化法（SP 法）对放化疗前后的宫颈鳞癌组织80例，CIN 90例以及正常宫颈组织30例的 APR3表达情况进行检测。结果：APR3在宫颈鳞癌中阳性表达率为81．25％，明显高于 CIN 组的31．11％以及对照组的10．00％（P ＜0．01）。放化疗后宫颈鳞癌组织中 APR3的表达率为51．25％，低于放化疗前81．25％（P ＜0．01）。APR3阳性表达率随临床分期的增高而增加（P ＜0．05），病理分化程度的降低而增加（P ＜0．05），有淋巴结转移者阳性表达率明显高于无转移者（P ＜0．05）。结论：APR3与子宫颈病变良恶性有关，与子宫颈鳞癌发生发展相关。放化疗可能影响宫颈鳞癌组织中 APR3的表达水平。