Objective To evaluate the significance of the serum lipid and apolipoprotein profiles on glycemic control in patients with type 2 diabetes mellitus. Methods A total of 53 patients with type 2 diabetes (30 men, 23 female) were collected in Loudi First People's Hospital from February to July 2012 by randomly selected,and fasting HbAlc,C Peptide (C P) ,tri glycerides (TG) ,total cholesterol (CHO) ,high density lipoprotein C (HDL C) ,apolipoprotein Al (ApoAl) ,apolipoprotein B (ApoB) and lipoprotein A (LPa) levels were measured. They were divided into three groups [group Ⅰ (C P≥0. 6 nmol/L and HbAlc ratio<6. 0%),group Ⅱ (C P>0. 6 nmol/L and HbAlc ratio>6. 0%) , group Ⅲ (C P<0. 6 nmol/L and HbAlc ratio≥6. 0%)] according to C Peptide and HbAlc levels. Results Multi variable analyses showed there were a significant differences in TG (F=4. 33,P<0. 05) ,CHO(F=6. 86,P<0. 05) ,ApoB (F=9. 32,P<0. 001) among three groups. How ever,there were no significant differences in LPa (F=0. 53, P>0. 05) , ApoAl (F= 1. 99, P>0. 05) , HDL C (F=5. 76, P >0. 05) among three groups. Highly significant positive correlations were observed between ApoAl and HDL C levels (r= 0.75,P<0.001) adjusted sex and age. Similarly,CHO and ApoB levels (r=0.78,P<0. 001) displayed a significant positive correlation. Conclusion Lpa is an independent risk factor influencing on the progression of disease with type 2 diabetes mel litus , and the TG is an important risk factor. HDL C/CHO ratio is a more appropriate marker of risk than HDL C levels, and ApoAl/CHO ratio is a more appropriate marker of risk than ApoAl levels.%目的 评价2型糖尿病患者血糖控制水平对血脂及脂蛋白的影响.方法 随机检测2012年2月～7月就诊的2型糖尿病患者53例,其中男性30例,女性23例,分别检测糖化血红蛋白比率(HbA1c )、C肽(C-P)、三酰甘油(TG)、总胆固醇(CHO)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A(ApoA1)、载脂蛋白B(ApoB)及脂蛋白A(LPa);依据HbA1c,C-P水平将其分为Ⅰ(C肽≥0.6 nmol/L及HbA1c比率＜6.0%),Ⅱ(C肽≥0.6 nmol/L及HbA1c比率≥6.0%)及Ⅲ(C肽＜0.6 nmol/L及HbA1c比率≥6.0%)三组.结果 多元方差分析结果表明:三组间TG(F=4.33,P<0.05),CHO(F=6.86,P<0.05),ApoB(F=9.32,P<0.001)差异均具有统计学意义,而LPa(F=0.53,P>0.05),ApoA1(F=1.99,P>0.05),HDL-C(F=5.76,P>0.05)差异无统计学意义;调整性别、年龄因素,相关分析结果表明:ApoA1与HDL-C(r=0.75,P<0.001),CHO与ApoB(r=0.78,P<0.001)分别呈正相关.结论 Lpa是2型糖尿病病情发展的独立风险因素,TG是重要影响因素.HDL-C/CHO优于HDL-C,ApoA1/CHO优于ApoA1.
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