目的:探讨参附注射液降低难治性脓毒休克患者对去甲肾上腺素剂量/时间依赖的有效性.方法:选择2014年10月至2016年9月入住我院重症医学科的难治性脓毒休克患者80例,随机分为进行常规治疗的对照组和常规治疗加参附注射液治疗的观察组,比较2组患者使用去甲肾上腺素总剂量、输注去甲肾上腺素总持续时间、输注去甲肾上腺素剂量＞0. 5 μg/ (kg ? min)持续时间,患者MAP达标时间、ICU住院时间、ICU住院死亡率.结果:观察组患者输注去甲肾上腺素总持续时间显著低于对照组 (P＜0. 05),2组患者输注去甲肾上腺素总剂量、MAP达标时间、ICU住院时间、ICU住院死亡率差异无统计学意义 (P＞0. 05).结论:参附注射液能够降低难治性脓毒休克患者对去甲肾上腺素的剂量/时间依赖,但不能降低患者ICU住院时间和ICU住院死亡率.%Objective: To explore the effectiveness of Shenfu injection on reducing norepinephrine dose/time dependence in patients with refractory septic shock. Methods: 80 patients with refractory septic shock were randomly divided into control group (receiving conventional treatment) and observation group (receiving conventional treatment plus Shenfu injection treatment). The total dose and duration of norepinephrine infusion, the duration of norepinephrine infusion dose ＞0. 5 μg/ (kg ? min), the duration reached MAP target value, ICU length of stay, ICU in-hospital mortality were compared between the two groups. Results: The total duration of norepinephrine infusion in the observation group was significantly lower than that in the control group (P ＜ 0. 05). There were no significant differences in the total dose of norepinephrine infusion, duration reached MAP target value, ICU length of stay and ICU in-hospital mortality between the two groups (P ＞ 0. 05). Conclusion: Shenfu injection can reduce the dose/time norepinephrine dependence in patients with refractory septic shock, but can not shorten ICU length of stay and decrease ICU inhospital mortality.
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