儿童血清25-羟维生素D水平与超声骨密度关系研究

摘要

目的 调查分析儿童血清维生素D营养状况及与超声骨密度关系,为科学合理补充维生素D及钙剂提供依据.方法 选取儿保科门诊常规体检的1~10岁儿童368名为研究对象,采用化学发光法测定血清25-羟维生素D水平,定量超声骨密度仪测取骨密度值.结果 所选儿童血清25-羟维生素D平均水平为(28.36±12)ng/ml,超声骨密度平均水平为(-0.07±0.10).随着年龄增加,维生素D水平逐渐下降,25-羟维生素D缺乏组、不足组中超声骨密度不足率均较充足的组别高(P<0.05),男女童25-羟维生素D及超声骨密度均值比较无统计学意义(P>0.05).6~岁年龄组25-羟维生素D与骨密度呈正相关(P<0.05).结论 泸州市儿童25-羟维生素D及超声骨密度普遍不足,两者仅在一定年龄可能有关,临床上应结合两种检查,科学合理补充维生素D及钙剂.%Objective To explore the relationship between serum 25-hydroxyvitamin D [25(OH)D] and ultrasonic bone mineral den-sity (BMD) in children so as to provide basis for scientific and reasonable supplement of vitamin D and calcium. Methods 368 children were selected from the clinic of Department of Pediatric Health Care;the level of serum 25(OH)D was measured by chemiluminescence while the individual BMD was measured by quantitative ultrasound. Results The average level of serum 25(OH)D was (28.36 ± 12)ng/ml while the average Z value of ultrasonic BMD was (-0.07±0.10);the level of 25(OH)D kept decreasing with the age growing;the low rate of ultrasonic BMD in children with vitamin D deficiency or with low level of vitamin D was higher than that of children with suffi-cient vitamin D (P<0.05);the comparative study between the average level of serum 25(OH)D and the average Z value of BMD was of no statistical significance (P>0.05);there existed a positive correlation between the level of serum 25(OH)D and the Z value of BMD in children aged from 6 to 7 years old (P<0.05). Conclusions The level of serum 25(OH)D and the Z value of ultrasonic BMD of children in Luzhou City, Sichuan Province are low while the correlation between the 2 exists in certain age stages;the combination of the 2 detec-tions may be of help for the scientific and reasonable supplement of vitamin D and calcium in clinic.