炎性因子与冠状动脉支架植入术后再狭窄的相关性研究

摘要

目的：探讨炎性因子与冠状动脉支架植入术后再狭窄发生的相关性。方法：收集我院近5年冠状动脉支架植入术患者80例，根据其是否发生再狭窄情况分为两组，比较其IL‐10、IL‐6、IL‐6／IL‐10、CRP水平。结果：80例患者中11例发生支架内再狭窄，再狭窄率13．75％；发生再狭窄患者与未发生狭窄患者术前IL‐6差异有统计学意义（ P＜0.05），术后两组IL‐6均明显增加（P＜0．05），且ISR组增加程度更为显著（P＜0．05）；术前两组患者IL‐10差异有统计学意义（P＜0．05），术后两组IL‐10均明显降低（P＜0．05），且ISR组降低程度更为显著（P＜0．05）；术前IL‐6／IL‐10差异无统计学意义（P＞0．05），但ISR组IL‐6／IL‐10增加显著（P＜0．05），无ISR组未出现明显变化（P＞0．05），两组术后差异有统计学意义（P＜0．05）；CRP术前差异无统计学意义（P＞0．05），术后ISR组明显增加（P＜0．05），且高于无ISR组（P＜0．05）。结论：IL‐10、IL‐6、IL‐6／IL‐10、CRP尤其是基础IL‐10、IL‐6水平与再狭窄发生密切相关，可以作为再狭窄发生的预测指标。%Objective :To investigate the correlation between inflammatory cytokines and in‐stent restenosis (ISR) after coronary stenting .Methods :80 cases of coronary stenting in recent 5 years of our hospital were divided into 2 groups ac‐cording to whether it is stent‐restenosis ,and comparing the level of IL‐10 ,IL‐6 ,IL‐6/IL‐10 ,CRP .Results:11 cases in 80 patients had stent‐restenosis ,costing 13 .75% ;there was statistical significance in IL‐6 level of patients with rest‐enosis and without restenosis before coronary stenting (P<0 .05) ,and after coronary stenting IL‐6 level of these two groups were significantly increased(P<0 .05) ,ISR group increased more significantly (P<0 .05);there was statistical significance in IL‐10 level for these two groups before coronary stenting (P<0 .05) ,while after coronary stenting two groups of IL‐10 were significantly decreased (P<0 .05) ,and ISR group decreased more significantly (P<0 .05);there was no significantly difference in IL‐6/IL‐10 before coronary stenting (P>0 .05) ,but the ISR group in IL‐6/IL‐10 in‐creased significantly(P<0 .05) ,but there was no significant different in the other group(P>0 .05) ,but after coronary stenting there was significant different between two groups (P<0 .05);before coronary stenting CRP has no signifi‐cant difference ,but after coronary stenting ISR was significantly increased (P< 0 .05) ,and higher than the other group (P<0 .05) .Conclusion:IL‐10 ,IL‐6 ,IL‐6/IL‐10 ,CRP are closely related to stent‐restenosis ,especially IL‐10 ,IL‐6 .They can be used as predictors of restenosis .