血清TK1对肺癌患者的诊断和复发评估价值的研究

摘要

Objective :To investigate the serum thymidine kinase 1(TK1) levels and its relevance in diagnosis and re-currence assessment of patients with lung cancer .Methods :Serum TK1 levels are detected in 28 cases of lung cancer pa-tients before surgery with 30 healthy persons as control to determine its diagnostic value .Then test the serum TK1 one week and one month respectively after surgical operation ,observe the changes and its relationship to relapse-free sur-vival (RFS) .Results:Average TK1 concentration of 28 patients with lung cancer (2 .954 ± 0 .176)pM was significantly higher than that in the healthy controls (1 .063 ± 0 .163)pM (P<0 .001) ,and it decreased significantly one month after surgery (1 .801 ± 0 .176)pM (P<0 .001) .Furthermore ,one month after surgery ,the relapse-free survival (RFS) of patients whose TK1 level achieved PR was significantly longer than that of SD +PD group (P<0 .05) .Conclusion:Ser-um TK1 as a new tumor marker has potential applications in the diagnosis and assessment of recurrence of lung cancer .%目的：探讨细胞质胸苷激酶1（TK1）在肺癌患者血清中的水平及其对肺癌的诊断价值和复发评估作用。方法：检测28例肺癌患者术前、术后1周和术后1个月的血清 T K1水平，同时选取30例健康体检者作为对照。比较分析各组TK1水平差异以及术后TK1变化情况与肺癌患者无复发生存率（RFS）的相关性。结果：28例肺癌患者的 TK1平均浓度为（2．954±0．176）pM ，显著高于正常对照组的（1．063±0．163）pM（P＜0．001），术后1个月 TK1水平较术前显著下降（1．801±0．176）pM （P＜0．001），且术后1个月TK1水平评估为PR组的患者无复发生存率（RFS）显著高于SD＋PD组（ P＜0．05）。结论：血清T K1作为一种新的肿瘤标志物，在肺癌的诊断和复发评估中有着潜在的应用价值。