生物陶瓷膜封堵器介入治疗对先天性心脏病的临床研究

摘要

Objective :To investigate clinical effect of interventional treatment of biological ceramic occluder in congeni‐tal heart disease .Methods :94 patients with congenital heart disease were selected in hospital from November 2011 to June 2013 .According to operation ,patients were divided into two groups .47 patients treated interventional treatment of common nitinol occluder as control group .47 patients treated interventional treatment of biological ceramic occluder as observation group .Patients followed up 6 months .Changes of cardiac index before and after treatment ;complica‐tions were compared between two groups .Results:After follow‐up ,left ventricular diastolic diameter ;left atrial diame‐ter ;right ventricular diastolic diameter ;right atrial diameter decreased in two groups while left ventricular ejection frac‐tion increased .Left ventricular diastolic diameter ;right ventricular diastolic diameter in observation group were signifi‐cantly less than control group .Left ventricular ejection fraction in observation group was significantly higher than con‐trol group .Incidence of complications in observation group was significantly lower than control group .Differences were statistically significant(P<0 .05) .Conclusion:Effect of interventional treatment of biological ceramic occluder in con‐genital heart disease is good ,which can significantly improve cardiac index .That also has less complications and high safety .%目的：探讨生物陶瓷膜封堵器介入治疗对先天性心脏病的临床效果。方法：选取本院2011年10月－2013年6月诊治的先天性心脏病患者94例，根据术式分为两组，47例患者采用普通镍钛合金封堵器介入治疗为对照组，47例患者采用生物陶瓷膜封堵器介入治疗为观察组，术后随访6个月，比较两组患者治疗前、后的心脏指标改变情况及并发症情况。结果：随访时，两组患者左心室舒张末期前后径、左房前后径、右心室舒张末期前后径、右房前后径均有所降低，而左心室射血分数均有所升高。观察组患者左心室舒张末期前后径、右心室舒张末期前后径均明显小于对照组，观察组患者左心室射血分数明显高于对照组，观察组患者并发症发生率明显低于对照组，差异均有统计学意义（P＜0．05）。结论：生物陶瓷膜封堵器介入治疗先天性心脏病的效果良好，可明显改善患者的心脏指标，并发症少且安全性高。