目的：研究Ataxin-3蛋白在胃癌的表达，探讨在胃癌组织病理学特征。方法：将患者标本固定、石蜡包埋、切片、免疫组化染色，通过半定量计分法判断结果，镜检采用双盲原则，由两位不同医师进行评分。结果：A taxin-3在正常胃黏膜中主要呈中、高度表达，总阳性率为100％；在胃癌组织及上皮内瘤变主要呈低强度表达，少数呈中等强度表达，和正常胃黏膜组织相比总阳性率显著降低（P＜0．01）；Ataxin-3表达与患者年龄、性别、肿瘤部位及大小及临床分期无关，与Lauren组织学分型有关，与混合型及弥漫型癌患者相比，肠型胃癌患者低、中度表达显著提高（P＜0.05）。结论：Ataxin-3蛋白可能与胃癌分化增殖有关，在胃癌的发生发展过程中起重要意义。%Objective :To study the expression of Ataxin-3 protein in gastric cancer and explore the histopathological features of gastric .Methods :The patient specimens were fixed ,and paraffi n-embedded ,sliced ,immunohistochemical staining ,judged by the results of semi-quantitative scoring method ,and took by the principle of microscopic double-blind ,scored by two different physicians .Results:Ataxin-3 in normal gastric mucosa was proposed high expression ,and the total positive rate was 100% .In gastric carcinoma and intraepithelial neoplasia expression ,it was with a low-inten-sity ,few showed moderate expression ,and compared with normal mucosal tissue phase ,the total positive rate was sig-nificantly lower (P<0 .01) .Ataxin-3 expression was not connected with patient’s age ,sex ,tumor location and size , and clinical stage ,but was related with histological type and Lauren .Compared with the mixed cancer patients and pa-tients with diffuse ,the intestinal type gastric cancer in low and moderate expression was significantly increased (P<0.05) .Conclusion:Ataxin-3 protein may be related to differentiation and proliferation of gastric cancer ,and it plays an important significance in the development of gastric cancer .
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