2型糖尿病患者TNF-α、IL-6及CRP与胰岛素抵抗相关性研究

摘要

Objective :To study TNF‐α,IL‐6 ,CRP and Insulin Resistance(IR) in Type 2 diabetes and to explore the re‐lationship of them .Methods :A total 111 Type 2 diabetes patients visiting the department of endocrinology in our hospi‐tal from August 2012 to August 2014 were selected ,and divided into 2 groups according to the body mass index ,inclu‐ding the obesity group (BMI>25)and normal weight group (BMI 18~25) .The FBG ,FINS ,TNF‐α,IL‐6 ,CRP were measured and IR were calculated in all the research objects ,and to conduct statistical analysis .Results:The FBG , TNF‐α,IL‐6 ,CRP level and HOMA‐IR in the obesity group were higher than the normal weight group(P<0 .01) ,and HOMA‐IR were positive correlated with the TNF‐α,IL‐6 ,CRP level(P<0 .01) .Conclusion:The TNF‐α,IL‐6 ,CRP lev‐el and HOMA‐IR were found significantly correlation ,the inflammatory response and IR in Type 2 diabetes can be known by detecting the serum levels of TNF‐α,IL‐6 and CRP .%目的：探讨胰岛素抵抗与肿瘤坏死因子‐α（TNF‐α）、白细胞介素‐6（IL‐6）及C反应蛋白（CRP）之间的关系及意义。方法：选择2012年8月－2014年8月在我院内分泌科住院的共111例2型糖尿病患者，分别根据各自的体重指数（BMI）分为肥胖组（BMI＞25）和正常体重组（BMI 18～25），各组分别测定血清空腹血糖（FBG）水平及空腹胰岛素（FINS）水平，应用放免法检测空腹血清TNF‐α、CRP及IL‐6的水平，并进行相关统计学分析。结果：肥胖组患者血清血糖、TNF‐α、CRP及IL‐6水平及 HOMA‐IR显著高于正常体重组，差异具有统计学意义（P＜0．01）；TNF‐α、CRP及IL‐6水平与 HOMA‐IR存在显著正相关（P＜0．01）。结论：2型糖尿病患者 TNF‐α、CRP及IL‐6水平与 HOMA‐IR存在显著相关性，检测2型糖尿病患者TNF‐α、CRP及IL‐6水平可了解其炎性反应水平及胰岛素抵抗的发生情况。