血清降钙素原与慢性阻塞性肺病急性加重期患者抗生素应用的相关性分析

摘要

目的：探讨血清降钙素原（PCT）与慢性阻塞性肺病急性加重期（AECOPD）患者抗生素应用的相关性。方法：选择我院2011年5月－2013年10月入院接受治疗的AECOPD患者190例作为研究对象，按照随机分配方法分为常规治疗组95例和PC T组95例。常规组按照常规抗生素指南进行给药，PC T 组根据PC T检测结果水平决定抗生素的使用（即当PCT水平＜0．25ng／ml时不予抗生素治疗，PCT＞0．25ng／ml时给予抗生素治疗）。结果：两组患者的抗生素使用率、使用时间比较差异均具有统计学意义（P均＜0．05）。根据实验室痰培养＋药敏结果，采用抗生素治疗，两组患者采用抗生素情况比较差异具有统计学意义（P均＜0．05）。结论：针对AECOPD的患者应当尽早进行血清PC T的检测，提高诊断的准确性，降低抗生素使用率，减少抗生素使用费用及住院费用。%Objective :To investigate the correlation between serum procalcitonin (PCT) and antibiotic application in a‐cute exacerbation of chronic obstructive pulmonary disease (AECOPD) .Methods :190 cases of AECOPD patients from 2011 May to 2013 October in our hospital were selected as research object ,they were randomly divided into routine group and PCT group .The routine group was treated in accordance with the conventional antibiotic guide ,PCT group was treated with antibiotic determined by the use of PCT test results (i .e .when the level of PCT <0 .25ng/ml no an‐tibiotic ,PCT>0 .25ng/ml antibiotics offered) .Results:Antibiotic use rate and the time using antibiotic between two groups exsisted statistically difference(P<0 .05) .Antibiotic treatment was taken on the basis of drug sensitivity of la‐boratory sputum culture ,antibiotics applied in the two groups had statistically difference (P<0 .05) .Conclusion:Ser‐um calcitonin peptide detection should be performed early for AECOPD patients to improve diagnosis accuracy reduce the use of antibiotics ,reduce antibiotic use and hospitalization cost .