S100A4和HIF-1α与卵巢浆液性囊腺癌预后的关系研究

摘要

Objective:To study the expression of S100A4 and HIF‐1αprotein in Ovarian Serous Cystadenocarcinoma , analyzed the relationship between the two proteins .Methods:Immunohistochemistry method was used to detect S100A4 and HIF‐1αproteins expression and analysis the correlation of proteins expression in Ovarian Serous Cystadenocarcino‐ma .Results:S100A4 and HIF‐1αin Ovarian Serous Cystadenocarcinoma showed a high expression .S100A4 protein ex‐pression in Ovarian Serous carcinoma was positive relation with HIF‐1αprotein expression .The expression of S100A4 and HIF‐1αprotein existed intimate relation with cisplatin‐based chemotherapy resistance (P<0 .05) .They are associ‐ated with overall survival ,longer the overall survival ,lower the expression (P< 0 .05) .Conclusion:Expression of S100A4 and HIF‐1α existed significant positive correlation .High S100A4 and HIF‐1α expression predicts cisplatin‐based chemotherapy resistance and the overall survival in Ovarian Serous Cystadenocarcinoma .%目的：探讨S100A4和 HIF‐1α与卵巢浆液性囊腺癌预后的关系。方法：收集50例卵巢浆液性囊腺癌，28例卵巢浆液性囊腺瘤和15例正常卵巢组织为对照，采用免疫组织化学法检测S100A4和HIF‐1α的表达，并分析与患者预后的关系。结果：S100A4和HIF‐1α在卵巢浆液性囊腺癌组织中高表达，而在卵巢浆液性囊腺瘤组和正常卵巢组中低表达或不表达。S100A4与HIF‐1α表达呈显著正相关性。S100A4与铂化疗耐药无统计学意义（P＞0．05），HIF‐1α与铂化疗耐药有密切关系（P＜0．05）。S100A4和 HIF‐1α同时表达与铂化疗耐药密切相关（P＜0．05）；同时S100A4和HIF‐1α阳性表达患者的生存时间较阴性者明显减少（P＜0．05）。结论：S100A4和HIF‐1α的表达促进卵巢浆液性囊腺癌的发生发展，并且与患者铂化疗耐药和生存时间相关。