舌下含服硝苯地平缓释片联合卡托普利治疗高血压急症的疗效评价

摘要

Objective:To assess the antihypertensive effects of single use of extended release nifedipine(NFP) tablets or Captopril(CTP) tablets and combination of these two drugs .Methods:135 cases of patients with hypertensive Crisis were randomly divided into three group ,each comprised 45 of them .The groups of patients received sublingual NFP or CTP alone served as control group ,with the groups of patients received both NFP and CTP as observation groups .Ob‐serve the changes of blood pressure (systolic blood pressure and diastolic blood pressure) and heart rate at the time be‐fore injection and 5 minutes ,10 minutes ,30 minutes ,1 hour ,2 hours ,4 hours ,6 hours ,8 hours after administration .Re‐sults:In NFP group ,the blood pressure significantly dropped 5minutes after oral ,and reached and maintained the maxi‐mal peak 1 hour after oral ,the total efficacy was 77 .8% ;in CTP group ,the blood pressure significantly dropped 4minutes after oral ,and reached and maintained the maximal peak 1~2 hours after oral ,the total efficacy was 84 .4% ;in the combined use of NFP and CTP group ,the blood pressure significantly dropped 5 minutes after oral ,and reached and maintained the maximal peak 30 minutes~2 hours after oral ,the total efficacy was 93 .3% .Three groups of heart rate has no obvious change(P>0 .05) .The combined use of NFP and CTP produced better effect in decreasing blood pressure than the sole use of NFP or CTP(P<0 .05) .Conclusion:Sublingual extended release NFP tablets and CTP tablets can get ideal antihypertensive effects in time for patients with hypertensive crisis .%目的：评价舌下含服硝苯地平缓释片联合卡托普利治疗高血压急症的降压疗效。方法：将我院收治的高血压急症患者135例随机分成3组，其中舌下含服硝苯地平缓释片组45例，舌下含服卡托普利片45例，同时含服硝苯地平缓释片、卡托普利片45例，观察三组用药前后血压、心率的变化。结果：硝苯地平组血压在用药后5min即开始下降，1h达到高峰并保持稳定，总有效率为77．8％；卡托普利组用药后4min开始下降，1～2h达到高峰，总有效率为84.4％；合用硝苯地平及卡托普利组用药后5min开始下降，30min～2h达到高峰，总有效率为93．3％；三组心率在用药前后无明显改变。合用硝苯地平及卡托普利组降压疗效明显好于硝苯地平组或卡托普利组（P＜0．05）。结论：舌下含服硝苯地平缓释片联合卡托普利片对高血压急症患者安全、有效，可作为高血压急症患者的应急用药。