胎膜早破孕妇宫颈支原体和衣原体感染情况及支原体药敏分析

摘要

目的 了解湖州市妇幼保健院因胎膜早破住院分娩的孕妇宫颈支原体和衣原体感染情况及支原体药敏分析.方法 选择湖州市妇幼保健院胎膜早破孕产妇208例为观察组,无胎膜早破分娩孕产妇100例为对照组,对观察组及对照组孕产妇的宫颈分泌物进行支原体培养+药敏检测.结果 观察组支原体、衣原体总感染率为47.12％ (98/208),支原体感染率44.71％(93/208),沙眼衣原体感染率为5.28％ (11/208),与对照组比较,观察组的UU、MH、CT总感染率及UU、MH感染率、CT感染率均较对照组升高(P＜0.05),且两组孕妇支原体感染中均无单一人型支原体MH感染,人型支原体MH感染均以与UU混合感染形式存在.沙眼衣原体感染中亦多半以与UU混合感染形式存在.支原体阳性标本药敏试验显示,解脲支原体UU、MH及UU联合MH对强力霉素、美满霉素、交沙霉素的敏感度较高,可达100％.结论 胎膜早破孕妇宫颈支原体检出率高提示孕妇胎膜早破与宫颈支原体感染密切相关,衣原体检出率虽然不高,但与对照组相比却明显升高,提示孕妇胎膜早破与沙眼衣原体感染也有一定的相关性,故建议在计划妊娠前、妊娠早、中晚期应进行筛查,做到早发现早治疗,性伴侣同时治疗,减少PROM的发生,提高生育质量.支原体药敏试验提示支原体对多种药物耐药,但对强力霉素、美满霉素、交沙霉素敏感度较高.%Objective To understand the situation of cervical Mycoplasma and Chlamydia infection in pregnant women of Huzhou Maternal and Child Health Care Hospital with premature rupture of fetal membranes and the drug sensitivity analysis of Mycoplasma.Methods Totally 208 cases of premature rupture of fetal membranes in Huzhou Maternal and Child Health-Care Center were selected as the observation group.100 cases of delivery pregnant women with no premature rupture of fetal membranes were as control group,Mycoplasma culture and drug sensitivity test of the cervical secretion of the observation group and the control group were performed.Results The total infection rate of Mycoplasma and Chlamydia in the observation group was 47.12％ (98/208),Mycoplasma infection rate was 44.71％ (93/208).Chlamydia infection rate was 5.28％ (11/208),Compared with the control group,the total infection rate of UU,MH,CT,and the infection of UU,MH and CT infection rate in the observation group were higher than those in the control group (P ＜ 0.05).And in the two groups of pregnant women mycoplasma infection,there was not a single Mycoplasma MH infection.Mycoplasma MH infection was in the form of mixed infection with UU.Chlamydia infection was also mostly in the form of mixed infection with UU.Drug sensitivity test of Mycoplasma positive samples showed higher sensitivity,UU,MH and UU combined with MH of doxycycline,minocycline,josamycin,up to 100％.Conclusion The detection rate of cervical Mycoplasma in premature rupture of fetal membranes suggests that the premature rupture of fetal membranes is closely related to the infection of cervical Mycoplasma.Chlamydia detection rate is not high.But compared with the control group significantly increased,suggesting that premature rupture of fetal membranes and Chlamydia infection has a certain correlation.The recommendations in the plan before pregnancy,the pregnancy early and late should be screened.We should do early detection and early treatment,sexual partners and treatment,and reduce the incidence of PROM and improve the quality of reproduction.Mycoplasma drug sensitivity test showed that Mycoplasma resistant to multiple drugs,but sensitive to doxycycline,minocycline,josamycin.