乳腺增生症超声血流与T细胞亚群的相关性

摘要

Objective To investigate the correlation between color Doppler ultrasound blood flow performance and the peripheral blood T cell subsets in patients with breast hyperplasia.Methods Eighty three cases of breast hyperplasia were detected by color Doppler ultrasound and the color Doppler flow imaging (CDFI) of the lesion was observed.The Vmax and resistance index (RI) was measured,and peripheral blood T-cell subsets were detected with fluorescence activated cell sorter technique.The correlation between ultrasonic blood flow and the change of T-cell subsets was analyzed respectively.Results Patients of breast hyperplasia had T-cell subsets disorder with CD3 + CD8 + declined and CD4 +/CD8 + increased.CD3 + CD8 + and Vmax were negatively correlated(r =-0.25,P ＜ 0.05) as well as CD3 + CD8 + and RI (r =-0.547,P ＜ 0.01).CD4 +/CD8 + and Vmax were positively correlated (r =0.373,P ＜ 0.01) as well as CD4 +/CD8 + and RI (r =0.464,P ＜ 0.01).Conclusion It's helpful to identify the condition of patients with breast hyperplasia through detected the Doppler blood flow and monitored the variations of peripheral blood T cell subsets at the same time.%目的 探讨乳腺增生症彩色多普勒超声血流表现与外周血T细胞亚群的相关性.方法 检测83例乳腺增生症患者的超声图像,观察病变区的彩色多普勒血流显像(color doppler flow imaging,CDFI),测量其最高血流速度Vmax和阻力指数(RI),应用流式细胞技术检测外周血中T细胞亚群,分别分析超声血流表现与T细胞亚群变化的相关性.结果 乳腺增生症患者有T细胞亚群失调,CD3+ CD8+下降,CD4+/CD8+上升,CD3+ CD8+与Vmax呈负相关(r=-0.25,P＜0.05);CD3+ CD8+与RI呈负相关(r=-0.547,P＜0.01);CD4+/CD8+与Vmax呈正相关(r=0.373,P＜0.01);CD4 +/CD8+与RI呈正相关(r=0.464,P＜0.01).结论 对于乳腺增生症患者,超声检测血流,同时检测外周血T细胞亚群的变化,有助于病情的判断.