连续肾脏替代治疗对脓毒症的作用机制探讨

摘要

脓毒症是机体对感染反应失调所致的危及生命的器官功能障碍,其发病率和病死率均较高,给社会带来了巨大的经济负担.脓毒症患者炎症反应和抗炎反应平衡紊乱,是其最主要的病理生理过程之一.尽管脓毒症的治疗方式多样,但是其治疗效果仍不令人满意.连续肾脏替代治疗(CRRT)在危重症中的应用日益广泛,特别是在脓毒症的救治中显示出其独特的优势,显著改善脓毒症患者生存率.CRRT通过调节免疫、器官支持、稳定内环境等机制发挥作用,从而达到改善免疫紊乱、保护器官功能、维持内环境稳态的治疗目的.%Sepsis is a life-threatening organ dysfunction caused by dysregulated immune response to infection, which has high rates of morbidity and mortality.The imbalance between the response to inflammation and that to anti-inflammation is one of the most important pathophysiological processes in patients with sepsis.Despite the variety of its treatment options, their therapeutic effects remain unsatisfactory.Continuous renal replacement therapy (CRRT) is gaining a wider application in critical care medicine, especially in the treatment of sepsis, which can significantly increase the survival rate of sepsis patients by immunity modulation, organ support, and internal environment stabilization, so as to improve the immune disorder, protect the organ functions, and maintain homeostasis in the body.