肝硬化基础上原发性肝癌的时间密度曲线研究

摘要

目的:应用MSCT的时间密度曲线(TDC)研究发生于肝硬化基础的肝癌的达峰时间(TTP)及峰值高度(PV)的变化,揭示癌变的血流动力学改变.方法:肝炎后肝硬化合并原发性肝癌病例32例,行MSCT动态增强扫描,观察时间密度曲线及分别得到TTP及PV,应用配对t检验进行统计学分析.结果:肝硬化实质与肝癌的TDC形态不同.两者之间TTP及PV均P＜0.05,有统计学意义,即肝癌强化早而强化程度低于肝脏实质.结论:通过肝硬化及肝癌TDC形态学及其指标TTP与PV明确提示它们不同的血流动力学变化.%Objective:To explore the time-density curve (TDC) changes of primary hepatocellular carcinoma based on hepatic cirrhosis with MSCT and to study the differences of TTP and PV between HCC and hepatic parenchyma so that to reveal the hemodynamic change betreen them. Methods: Thirty-two cases were primary hepatocellular carcinoma based on cirrhosis. The target scans of each case were performed dynamic scanning within total 30 times. And the TDCs were got and all eases' time to peak (TTP) and peak value (PV) of hepatie parenchyma and HCC were obtained. The paired-sample test was applied to determine difference of TTP/PV berween hepatic parenchyma and PHC mass. Results: The TDC tendtency of hepatic parenchyma and PHC were different. Significant differences of the TTP and PV were observed between hepatic parenchyma and HCC ( P ＜0. 05. respectively). Compared with the TTP and PV of hepatic parenchyma,the mass decreased. Conclusion:TDC, TTP and PV can represent hemodynamic changes of HCC based on cirrhosis.