实时组织弹性成像在高海拔地区定量诊断肝纤维化

摘要

Objective To observe the value of real-time tissue elastography (RTE) with a new quantitative technology for the assessment of liver fibrosis stage in high altituderegions. Methods RTE was performed in 58 patients with liver fi-brosis and chronic hepatitis B. Eleven parameters obtained from the Real-time tissue elastography were analyzed with principal component analysis and comprehensive evaluation, then the elasticity index was obtained. The elasticity index was compared with liver fibrosis stage. Results The spearman's correlation coefficient between the elasticity index and the liver fibrosis stag was 0. 87, which was highly significant ( P<0.001). Elasticity index increased significantly with the degree of liver fibrosis increase. The areas under receiver operating characteristic curves indicating dianoslic accuracy were 0. 947 (S≥S1, P<0. 001) for the diagnosis of liver fibrosis, 0. 916(S≥S,2, P <0. 05), 0. 823(S≥S3, P<0. 05), 0. 717(S= S4, P >0. 05), restpectively. Conclusion RTE has a high clinical value in quantitative diagnosis of liver fibrosis .%目的 探讨在高海拔地区应用实时组织超声弹性成像(real-time tissue elastography,RTE)定量诊断肝纤维化的价值.方法 应用RTE对58例高海拔地区慢性乙肝患者肝脏进行检查,获取11个弹性参数,对其进行分析得到弹性指标,并与肝纤维化程度进行对照.结果 弹性指标与肝纤维化程度高度相关性,相关系数为0.87(P＜0.001),随着肝纤维化程度的增加弹性指标显著增加.RTE阳性为标准绘制ROC曲线图,ROC曲线下面积分别为0.947(S≥S1,P＜0.001)、0.916(S≥S2,P＜0.05)、0.823(S≥S3,P＜0.05)、0.717(S=S4,P＞0.05).结论 RTE在定量诊断肝纤维化中具有一定的临床价值.