Objective To investigate value of high b-value DWI on early efficacy of gliomas after surgical resections fol-lowed by comprehensive treatments .Methods 22 patients with gliomas after combined therapies for 3~4 weeks under-went high and low b-value (1 000/3000 s/mm2 ) DWI scanning .The regions of interest (ROI) were set at the edge of the original surgery area within 2 cm and the contralaters white matter areas ,then the min-ADC values were measured ,and their ratio (rADC) was further calculated .Besides ,optimum threshold was determined by using ROC ( receiver operating characteristic) curve analysis .Results All patients were divided into progression and non-progression groups based on their second postoperative pathologies or their long-term follow-ups after surgical resections followed by comprehensive treatments at the early period (3~4 weeks) ,among which 9 patients were lined in the progressive group ,while the re-mains were in the other group .Optimum threshold of values acquired by low (b=1 000 s/mm2 ) and high (b=3 000 s/mm2 ) b-value method were 1 .69 and 1 .68 .Diagnostic sensitivity ,specificity and accuracy of rADC by low (b=1 000 s/mm2 ) b-value method were 61 .5% ,55 .6% ,54 .5% ,those of rADC by high (b=3 000 s/mm2 ) b-value method were 76.9% ,100% ,86 .4% .Conclusion The high b-value (b=3 000 s/mm2 ) DWI scanning can be used in evaluating the treatment efficacy after surgical resections followed by comprehensive treatments at the early period (3 to 4 weeks) .%目的：探讨高b值DWI在脑胶质瘤术后综合治疗后早期疗效的价值。方法对22例脑胶质瘤术后综合治疗后3～4周患者进行高/低b值（3000/1000s/mm2）的DWI检查，感兴趣区（ROI）放置在原手术区边缘2cm以内和对侧正常脑白质区，分别测得感兴趣区内最小ADC值并计算出二者比值（rADC），最佳诊断阈值通过对rADC进行ROC曲线分析获得。结果根据二次手术病理证实或临床随访对22例脑胶质瘤术后综合治疗后早期（3～4周）检查的患者进行分组，其中，进展组9例、非进展组13例；最佳诊断阈值分别为1．69（b＝1000s/mm2）和1．68（b＝3000s/mm2），诊断敏感性、特异性和准确性分别为61．5％、55．6％、54．5％（b＝1000s/mm2），76．9％、100％、86．4％（b＝3000s/mm2）。结论高b值（b＝3000s/mm2）DWI扫描能够对脑胶质瘤术后综合治疗后的早期（3～4周）疗效进行准确评价。
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