水中高度分散的纳米羟基磷灰石分散剂的选择

摘要

采用粒度分析和测定zeta电位的方法研究了三种分散剂,包括十二烷基硫酸钠(DSS)、聚乙烯醇(PEG)和六偏磷酸钠(NaP)对纳米羟基磷灰石(HA)在水中分散行为的影响.结果显示,使用六偏磷酸钠作为分散剂可以使纳米羟基磷灰石在水中高度分散,形成溶胶.当NaP/HA=12.5(重量比)时,溶胶含有88%粒径在65-86nm之间的纳米粒子,可以用作给药系统中的药物载体.%In this study, three different types dispersants including an anionic surfactant dodecyl sodimn sulphate (DSS), an nonionic surfactant polyethylene glycol (PEG) and a kind of inorganic anion polyelectrolyte sodium hexametaphosphate (NaP) were used for the dispersion of nano HA crystals in water. The influence of the dispersants on the dispersion behavior of nano HA particles was compared by particle size distribution analysis and zeta potential determination. A highly dispersed sol was obtained when NaP was used. The nano HA sol,which contains 88% nanoparticles with size distribution between 65-86nm when NaP/HA = 12.5, can be used for drug delivery system.