泊马度胺治疗难治复发性多发性骨髓瘤的研究进展

摘要

泊马度胺是新一代的免疫调节剂(IMiD),因其在针对难治复发性多发性骨髓瘤(RRMM)的临床试验中显示出了令人鼓舞的疗效,被美国FDA批准用于至少经过两种治疗无效(包括来那度胺和硼替佐米)和最后一次治疗后60 d内病情恶化的患者.文章主要对泊马度胺在RRMM治疗中的研究进展进行综述.%Pomalidomide,which represents a new generation of immunomodulatory drugs (IMiD),has brought a major shift in therapeutic paradigm in treating relapsed and refractory multiple myeloma (RRMM).Considering its encouraging effectiveness,the U.S.Food and Drug Administration (FDA) approved its usage to treat patients who fail to respond to at least two prior therapies,including lenalidomide and bortezomib,and whose disease progressed within 60 days of the last treatment.This review summarizes the mechanisms of action and clinical activity of pomalidomide in treating RRMM.