冻融胚胎移植周期添加小剂量人绒毛膜促性腺激素对妊娠结局影响的临床研究

摘要

Objective To investigate into the impact of endometrium preparation with adding small doses of human chorionic gonadotropin (hCG) in frozen-thawed embryos transfer (FET) cycle on clinical outcomes.Methods A retrospective analysis of FET cycle of 156 cases. Patients were divided into two groups, hCG group and the control group, according to the endometrial preparation program. We compared their embryo implantation rate, clinical pregnancy rate as well as endometrial blood flow, thickness, type, etc. Results Compared to the control group, the clinical pregnancy rate, embryo transfer rate, type I rate of endometrial blood flow, endometrial thickness on hCG trigger and transfer day, resistance index (RI) of basal artery blood flowand radiation artery flow were better than the control group, and the difference was statistically significant (P ＜ 0.05) . However, the abortion rate, ectopic pregnancy rate, biochemical pregnancy rate, time averaged maximum velocity, time averaged maximum velocity (TAMAX) of basal artery or radiate artery, systolic/diastolic ratio (S/D) and pulsatility index (PI) of basilar artery, S/D and PI of radiation artery showed no statistical significance (P＞ 0.05) . Conclusion The addition of a small dose of hCG during FET cycles can improve the endometrial blood flow of patients, presenting a feasible method to promote embryo implantation and improve the clinical pregnancy rate.%目的 探讨冻融胚胎移植 (FET) 周期添加小剂量人绒毛膜促性腺激素 (hCG) 对妊娠结局的影响.方法 回顾性分析进行FET的156例周期,根据是否给予小剂量hCG注射分为hCG组和对照组,比较2组患者基线资料及胚胎种植率、临床妊娠率以及子宫内膜血流、厚度、分型等指标.结果 hCG组临床妊娠率、胚胎种植率、子宫内膜I型血流分型、hCG扳机日及移植日子宫内膜厚度、血流分支、基底动脉阻力指数 (RI) 、放射动脉RI均优于对照组,差异具有统计学意义 (P＜0.05);而2组流产率、异位妊娠率、生化妊娠率、基底动脉与放射状动脉脉搏时间平均血流速度 (TAMAX) 、搏动指数 (PI) 、收缩期与舒张期血流速度比值 (S/D) 、放射动脉TAMAX、放射动脉PI及S/D等指标差异均无统计学意义 (P＞ 0.05).结论 FET周期中添加小剂量hCG能够改善患者的子宫内膜血流,是促进胚胎种植、提高临床妊娠率的一种可行方法.