Objective To investigate the value of neutrophil to lymphocyte ratio (NLR) in predicting in-stent restenosis (ISR) in patients with coronary heart disease. Methods We collected the data of 618 patients with coronary heart disease hospitalized in the Department of Cardiology in the First Affiliated Hospital of Kunming Medical University from January 2011 to June 2012. All selected patients underwent coronary angiography and stent implantation, and were divided into two groups according to the average size of NLR. The relationship between the neutrophil to lymphocyte ratio and coronary heart disease in-stent restenosis was investigated. Results There were statistically significant differences in the presence of diabetes, high density lipoprotein, low density lipoprotein, the percentage of neutrophils and lymphocytes in patients between two groups (P<0.05) . We found 13 patients (4.2%) and 32 patients (10.4%) with in-stent restenosis in the first group and the second group, respectively, and there was a statistically significant difference between two groups (P<0.01) . Conclusion Neutrophil to lymphocyte ratio is correlated with ISR,and has clinical value in predicting ISR.%目的探讨中性粒细胞/淋巴细胞比率（NLR）对冠心病支架内再狭窄（ISR）的预测价值．方法收集昆明医科大学第一附属医院2011年1月至2012年6月心内科住院的冠心病患者618例，所有患者均行冠脉造影及支架植入术，根据NLR大小平均分为两组，探讨中性粒细胞/淋巴细胞比率与冠心病支架内再狭窄的关系．结果患者在有无糖尿病，高密度脂蛋白（HDL），低密度脂蛋白（LDL），中性粒细胞百分率，淋巴细胞百分率的差异有统计学意义（P<0.05）．第1组13例（4.2%）支架内再狭窄，第2组32例（10.4%）支架内再狭窄，两组在ISR的差异有统计学意义（P<0.01）．结论中性粒细胞/淋巴细胞比率与ISR发生率具有相关性，为预测ISR的发生有一定的临床价值．
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