Objective To explore the dangerous factors of diabetic ophthalmoplegia.Methods We collect-ed 32 cases of patients with diabetic ophthalmoplegia during January 2010 to January 2015 in endocrinology department of the affiliated hospital of Jining medical university endocrinology diagnosis of as diabetic oph-thalmoplegia group(OMP group).And randomly over the same period 32 cases of no ophthalmoplegia in pa-tients with type 2 diabetes in hospital as diabetes group(DMgroup).Gathering the general information (age, gender,plasma lipid levels,glycosylated hemoglobin)and steamed bread meal test results were retrospective-ly analyzed.Application of statistical methods came to the conclusion.Results In OMP group low density lip-oprotein cholesterol(LDL),fasting blood sugar(FPG)and postprandial 2hours blood glucose(2hPG)were significantly higher than that of DM group,and the difference was statistically significant(P <0.05).Fasting and postprandial 2hour C peptide (2hC peptide)levels were lower than that in group DM,and the difference was statistically significant(P <0.01 ).Multivariable logistic regression analysis found that LDL and 2-h C peptide,the difference was statistically significant(P<0.05).Conclusion High LDL and low postprandial 2h C peptide levels are risk factors for the onset of diabetic ophthalmoplegia.Therefore,for patients with type 2 diabetes on the basis of strict control of blood sugar should also adjust blood lipid metabolism,improve the function of islet beta maintain C peptide levels on the prevention and cure of diabetic ophthalmoplegia.%目的：探讨糖尿病性眼肌麻痹的危险因素。方法收集2010年1月至2015年1月期间就诊于济宁医学院附属医院内分泌科确诊为糖尿病性眼肌麻痹患者32例作为糖尿病性眼肌麻痹组（OMP 组），并随机抽取同期住院无眼肌麻痹的2型糖尿病患者32例作为糖尿病组（DM组）。收集其一般资料（年龄、性别、血脂、糖化血红蛋白）及馒头餐试验结果进行回顾性分析。结果OMP 组低密度脂蛋白胆固醇（LDL）、空腹血糖（FPG）及餐后2h 血糖（2hPG）明显高于 DM组，差异有统计学意义（P ＜0．05）；空腹及餐后2h C 肽（2h C 肽）水平均明显低于 DM组，差异有统计学意义（P ＜0．01）。两组资料间应用多因素 logistic 回归分析方法显示 LDL 及2h C 肽差异有统计学意义（P ＜0．05）。结论高水平 LDL 及低水平餐后2hC 肽是糖尿病性眼肌麻痹发病的危险因素。因此，对于2型糖尿病患者在严格控制血糖的基础上还应调节血脂代谢，改善胰岛β功能维持 C 肽水平对糖尿病性眼肌麻痹的防治有指导意义。
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