阿尔茨海默病中的氧化应激及抗氧化治疗

摘要

Redox impairment is a prominent feature of Alzheimer's disease (AD).The “oxidative stress hypothesis”,supposes that oxidative stress (OS)occurs earlier than the mild cognitive impairment and molecular events (β-amyloid plaques and neurofibrillary tangles),leading to cell and tissue dama-ges and therefore promoting the disease progression.The markers for oxidative damage,alterations of the specific activity of the antioxidant system and mitochondrial disturbances,are in close connection with tau phosphorylation and aggregation,and the amyloid plaques.Thus,based on the oxidative stress hypothe-sis,the present paper reviews antioxidants as beneficial therapeutic tools in AD treatment and the antioxi-dant research in the future.%氧化损伤是阿尔茨海默病（AD）的一个重要特征，故“氧化应激假说”提出 AD 中氧化应激产生较早，可在轻度认知功能障碍及分子水平改变出现即β淀粉样蛋白沉积及神经纤维缠结的形成之前，导致细胞和组织损伤，促进疾病进展。氧化应激中增高的氧化损伤标记水平、抗氧化系统中特定活性的改变、线粒体功能失调及与 tau蛋白磷酸化及聚集，β淀粉样蛋白斑块之间联系紧密。本综述探讨 AD 中的氧化应激假说，抗氧化治疗 AD 中的可行性及展望。