芦沙坦对大鼠动脉血压和缰核神经元自发放电活动的影响

摘要

Objective:To investigate whether the habenula takes part in the depressor effect of losartan.Methods:Arterial blood pressure,heart rate and the unit dischargings of habenular neurons in rat were recorded simultaneously.Results:Arterial blood pressure was apparently decreased by 10 mg/kg losartan intraperitoneally(ip),but heart rate did not change;63.64% (21/33) unit dischargings of habenular neurons was increased in the rate of discharges.Conclusion:The depressor effect of losartan (ip) may be involved in the excitation of habenular neurons by lsoartan(ip).%目的：探讨缰核是否参与芦沙坦外周降压过程的调节。方法：记录大鼠的股动脉血压和心率的同时，用玻璃微电极记录缰核神经元自发单位放电。结果：腹腔注射10 mg/kg芦沙坦可显著地降低大鼠动脉血压，但对心率无明显的影响；芦沙坦可使缰核64%(21/33)自发单位放电的放电频率增加。结论：腹腔注射芦沙坦可兴奋缰核神经元产生降压效应。