老年冠心病患者血清胱抑素C水平与冠状动脉狭窄程度的相关性研究

摘要

Objective To study the clinical predictive value of Cystatin C(Cys C)level to coronary artery stenosis degree of aged Coronary Heart Disease(CHD). Methods Retrospectively analyzed 185 cases of aged CHD diagnosed with coronary angiography. According to the results of coronary an⁃giography,185 cases were divided into single lesion group(89 cases)and multivessel lesions group (96 cases),detected Cys C level and graded Gensini score in all selected cases,analyzed the differ⁃ence of level of Cys C,also the correlation of Cys C level and the coronary artery Gensini score in two groups. Results (1)The Cys C levels in multivessel lesions group((1. 55±0. 32)mg/L)was obviously higher than that in single lesion group ((1. 28 ± 0. 20)mg/L)(P<0. 01). (2) In two groups,the Cys C levels were positive correlated with Gensini score(multivessel leisions group,r=0. 78,P<0. 01;single lesion group,r=0. 75,P<0. 01). Conclusion With Cys C level detecting, the coronary artery lesion degree can be predicted,as the increasing of Cys C level,the artery steno⁃sis degree become more seriously.%目的：研究血清胱抑素C（Cys C）水平对老年冠心病患者冠状动脉狭窄程度的临床预测价值。方法回顾性分析185例经冠脉造影诊断为冠心病的老年患者，根据冠状动脉造影检查结果分为单支病变组（89例）及多支病变组（96例），对所有入选患者进行Cys C检测并进行Gensini评分，分析比较两组患者Cys C水平的差异及Cys C与冠状动脉照影Gensini评分的相关性。结果（1）多支病变组血清胱抑素C水平（1.55±0.32）mg/L明显高于单支病变组（1.28±0.20）mg/L（P＜0.01）。（2）两组患者血清胱抑素C水平均与冠脉造影Gensini评分呈正相关（多支病变组r=0.78，P＜0.01；单支病变组r=0.75，P＜0.01）。结论 Cys C水平检测能预测老年患者冠状动脉病变严重程度，且随着Cys C水平的增高，冠状动脉狭窄程度加重。