植物蛋白乙酰化/去乙酰化与代谢和基因表达调控研究进展

摘要

Lysine acetylation of histone plays an important role in regulation of gene expression in plant cells ,meanwhile it affects the enzyme activity of glycolysis ,tricarboxylic acid cycle and photosynthetic pathway. Therefore ,it is of great significance to identify histone acetyltransferase(HAT) and histone deacetylase(HDAC) of metabolism regulating enzymes. On the contrary ,metabolites such as acetyl-CoA and NAD+are involved in processes of protein acetylation and deacetylation ,their intracellular levels may influence on activity of HAT and HDAC. This paper illustrates the role of HAT ,HDAC and their research progress from protein lysine acetylation process ,classification and cell distribution ,and metabolic enzyme activity.%植物细胞中组蛋白赖氨酸乙酰化修饰对基因表达具有重要的作用，同时影响糖酵解、三羧酸循环和光合作用途径中非组蛋白的代谢酶活性。因此，识别参与调控代谢酶活性的HAT和HDAC具有重要意义。相反，代谢物如乙酰-CoA和NAD+参与蛋白可逆乙酰化进程，并且它们在细胞内的水平可能影响组蛋白乙酰化酶和组蛋白去乙酰化酶的活性。从组蛋白质赖氨酸乙酰化可逆过程、蛋白乙酰化酶和组蛋白去乙酰化酶分类及其细胞内分布和代谢酶的活性研究阐述了HAT和HDAC的作用及其研究进展。