随着正电子发射断层(Positron Emission Tomography,PET)显像技术在检测肿瘤、神经精神疾病和心脏疾病等方面的广泛应用,正电子核素18F标记多肽作为PET示踪剂,近年来得到了快速发展,目前已有多种18F标记多肽的方法.本文以标记反应的特点,总结了以下七种18F标记多肽的方法:1)18F标记辅基法；2)固相标记法；3)18F-A1F络合标记法；4)点击化学法；5)18F-19F同位素交换法；6)芳香环亲电、亲核氟标法；7)其他标记法.并对各种方法的优缺点进行了比较.%With the wide use of positron emission tomography (PET) imaging for the detection of cancer, neurological diseases, and cardiovascular diseases, peptides labeled with positron-emitting radionuclide (18F) as the promising PET tracers have been made rapid development in recent years. There are many methods for 18F-labeled peptides. According to the characteristics of the labeling reactions, this review summarized the methods of 18F-la-beled peptide as follows; 1) 18F-labeled prosthetic group method; 2) solid-phase labeling method; 3) 18F-A1F labeling method; 4) click reaction; 5) 18F-19F isotope exchange method; 6) aromatic electrophilic or nucleophilic labeling method; 7) the other labeling methods. Furthermore, these methods' advantage and disadvantage were analyzed.
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