目的 观察用自制新型左心耳封堵器堵闭犬左心耳后对左房及毗邻解剖结构的影响.方法 用自行研制的新型左心耳封堵器经导管封堵20只犬的左心耳.分别于术前和术后行经胸心脏超声检查,测量左房内径和容积,以及左上肺静脉血流速度和左房室瓣血流速度;并于术后行左心耳造影及左冠状动脉造影.结果 14只犬成功植入封堵器.术后经胸超声及造影检查见封堵器无移位,左心耳完全堵闭,封堵器植入后左房内径和容积,以及左上肺静脉血流速度和左房室瓣血流速度无明显变化,左冠状动脉回旋支正常显影.结论 用自行研制的新型左心耳封堵器堵闭犬左心耳不影响左房以及毗邻解剖结构的功能,此方法安全可行.%Objective To observe the effect of percutaneous transcatheter occlusion of left atrial appendage (LAA) with a new self-manufactured LAA occluder on left atrium and adjacent anatomic structure in canine. Methods A new self-manufactured LAA occluder was implanted into the LAA through a transseptal catheter in 20 dogs. Before and after the procedure, the experimental dogs were anaesthetized and examined by transthoracic echocardiography (TTE) to measure the diameter and the volume of the left atrium, the left superior pulmonary vein flow velocity and the left atrioventricular valve flow velocity separately. The contrast radiography of the LAA and the left coronary arteriography were performed. Results The new LAA occluder was implanted successfully in 14 dogs. No obvious changes in the diameter and the volume of the left atrium, in left superior pulmonary vein flow velocity and in left atrioventricular valve flow velocity were found. On arteriography, left circumflex artery was normally displayed after the procedure. No migration of the occluder was seen on TTE and angiography after procedure. Conclusion Percutaneous transcatheter occlusion of left atrial appendage with a new self-manufactured LAA occluder has no obvious effect on left atrium and adjacent anatomic structure in experimental canine, which indicates that the new-type device is a safe and feasible occluder for LAA.
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