Objective To investigate the clinic effects of transcatheter arterial chemoembolization (TACE) combined with injection of hyper- thermic lipiodol into tumor body in treating large hepatic carcinoma. Methods A total of 86 patients with primary hepatic carcinoma were randomly and equally divided into the study group (n = 43) and control group (n = 43). TACE combined with injection of hyper-thermic lipiodol into tumor body was carried out in the patients of the study group , while only TACE was performed in the patients of the control group. The results were compared between the two groups. Results The effective rate of the study group and the control group was 68%and 53%respectively , and the difference between the two groups was statistically significant. The difference in the changes of tumor size after the treatment between the two groups was also statistically significant. In the study group, the survival rates at 6, 12, 18 and 24 months after the treatment were 100% (n = 43), 84% (n = 36), 53% (n = 23) and 33%(n=14) respectively, while in the control group the survival rates were 94% (n=40), 70% (n=30), 37%(n = 16) and 21%(n = 9) respectively. No statistically significant differences in postoperative liver function damage existed between the two groups. Conclusion TACE combined with injection of hyper-thermic lipiodol into tumor body is obviously superior to routine TACE in treating large hepatic carcinoma.%目的：探讨经肝动脉化疗栓塞术（TACE）联合经皮肝穿刺注射热碘油治疗大肝癌的临床疗效。方法86例原发性肝癌随机分为2组，43例患者采用TACE术后并经皮肝穿刺注射热碘油治疗作为治疗组；另外43例患者TACE治疗作为对照组。结果治疗组有效率为68%，对照组有效率为53%，两组间差异有统计学意义（P<0.05）。两组术后肿瘤大小变化差异有统计学意义（P<0.05）；术后随访6、12、18、24个月生存例数和生存率分别为：43例（100%），36例（84%），23例（53%），14例（33%）；对照组分别为：40例（94%），30例（70%），16例（37%）和9例（21%）。但两组术后肝功能损害比较差异无统计学意义。结论经皮肝穿刺注射热碘油联合TACE治疗原发性肝癌的效果明显优于常规TACE治疗。
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