目的 探讨无水乙醇联合组织胶硬化栓塞治疗儿童高回流静脉畸形的临床效果.方法 回顾性分析2009年4月至2014年10月全身麻醉下介入硬化剂治疗的339例静脉畸形患儿临床资料.对137例高回流静脉畸形患儿施行无水乙醇联合α-氰基丙烯酸正丁酯(NBCA)硬化栓塞治疗.术后随访6～24个月,平均15个月.结果 137例高回流静脉畸形患儿均成功接受无水乙醇联合NBCA胶治疗,其中23例治愈,31例基本治愈,42例有效(好转),总有效率为70％(96/137).1例NBCA胶回流导致异位栓塞,8例皮肤破溃,3例术中出现一过性肺动脉高压,不良反应发生率为8％(12/137).结论 无水乙醇联合NBCA胶硬化栓塞治疗儿童高回流静脉畸形,是一种安全有效、不良反应发生率低的治疗方法.%Objective To evaluate the clinical efficacy of absolute ethanol combined with histoacryl sclerotherapy in treating high-reflux venous malformation in children.Methods The clinical data of a total of 339 sick children with venous malformation,who were admitted to authors' hospital during the period from April 2009 to April 2014 to receive interventional sclerotherapy under general anesthesia,were retrospectively analyzed.Sclerotherapy with absolute ethanol combined with N-butyl cyanoacrylate (NBCA) was carried out in 137 sick children with high-reflux type venous malformation.The patients were followed up for 6-24 months (mean of 15 months).Results Successful sclerotherapy with absolute ethanol combined with NBCA was achieved in all 137 sick children with high-reflux type venous malformation.Complete cure was obtained in 23 sick children,basic cure in 31 sick children,and effective response (improvement) in 42 sick children;the total effective rate was 70％ (96/137).Ectopic embolization due to reflux of NBCA occurred in one sick child,skin ulceration was seen in 8 sick children and intraoperative transient pulmonary hypertension was observed in 3 sick children.The adverse reaction rate was 8％(12/137).Conclusion For the treatment of high reflux venous malformation in children,sclerotherapy with absolute ethanol plus NBCA is safe and effective,this technique carries low incidence of adverse reactions.(J Intervent Radiol,2017,26:217-220)
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