抗苗勒管激素用于多囊卵巢综合征诊断的探讨

摘要

目的:探讨抗苗勒管激素(AMH)在多囊卵巢综合征(PCOS)诊断的应用价值.方法:用电化学免疫发光法检测75例PCOS患者(研究组)及86例正常排卵育龄妇女(对照组)月经第2日内分泌水平,酶联免疫吸附法(ELISA)检测血清AMH,同时应用超声诊断仪行卵巢卵泡计数(FN).结果:①研究组与对照组血清AMH水平分别为(8.21±2.32) mg/L和(2.39±1.29) mg/L,研究组AMH水平明显高于对照组.②研究组AMH与FN、睾酮(T)、黄体生成激素(LH)、LH/FSH呈正相关(r分别为0.489,0.215,0.312和0.256,均P＜0.05),而与卵泡刺激素(FSH)、雌二醇(E2)、泌乳素(PRL)、体质量指数(BMI)无线性相关性(r分别为0.12,0.19,0.10和0.16,均P＞0.05).结论:AMH用于临床PCOS诊断有一定价值,且简便易行.%Objective:To explore whether anti-mullerian hormone (AMH) measurement in the serum could be a marker for diagnosis of polycystic ovary syndrome (PCOS). Methods: Serum AMH was measured with immunoassay in a cohort of 75 PCOS patients and 86 controls,and follicle number was estimated by ultrasound scanning. Results:Serum AMH levels were 4-fold higher in PCOS patients than in control group [ (8.21±2.32) mg/L vs. (2.39±1.29) mg/L] ,and were significantly related to the follicle number in the two groups. In PCOS patients, AMH concentrations correlated with the number of ovarian follicles,testosterone 、LH and LH/FSH(r= 0.489,0.215,0.312 and 0.256,P<0.05) ,but not related with FSH、E2 PRL and BMI (r=0.12,0.19,0.10 and 0.16,P>0.05).ConcIusions:The serum AMH level was a marker which may be used for diagnosis of the PCOS.