缺氧诱导因子1α和VEGF及其受体与妇科恶性肿瘤

摘要

Hypoxia inducible factor-lalpha(HIF-lα) is a major transcription factor that wide]y exists in mammal and human body in case of hypoxia. HIF-lα activates target genes to transcript and makes the organisms to adapt the hypoxic microenvionment. Also it plays key roles in tumor angiogenesis. Vascular endothelial growth factor(VEGF) is an important target gene of HIF-lα and the receptor KDR is a crucial receptor of VEGF. In recent years a large amount of studies indicate that HIF-lα, VEGF, KDR proteins in a variety of tumors shows high expression and positivoly associated with each other. Here we make a review of HIF-lα, VEGF, KDR for their molecular biology, their functions in tumor functions and the reseach progress in gynecological tumors.%缺氧诱导因子lα(HIF-1α)是缺氧条件下广泛存在于哺乳动物和人体内的一种转录因子,其能启动靶基因转录,使机体适应缺氧的微环境,在肿瘤血管生成等方面起重要作用.血管内皮生长因子(VEGF)的基因是HIF-lα重要的靶基因,而VEGF受体(KDR)是VEGF的主要功能受体.近年研究表明,HIF-1α,VEGF,KDR在多种肿瘤组织中呈高表达,且三者间存在着一定的正相关关系.综述HIF-1α,VEGF,KDR的分子生物学特点及其在调节肿瘤血管生成方面及妇科恶性肿瘤中的研究进展.